Grants
Indiana CTSI administers more than $1.1 million to advance translational research across Indiana
Sept. 12, 2013
Researchers at Indiana University, Purdue University and the University of Notre Dame have received more than $1.1 million through the Indiana Clinical and Translational Sciences Institute in support of research projects that aim to accelerate the transformation of novel scientific discoveries into new medical treatments and therapies.
2013 Collaboration in Translational Research Grants
Nine research teams from IU, Purdue and Notre Dame will receive more than $600,000 through the Collaboration in Translational Research grant program. CTR grants support early-stage research projects with the potential to attract additional support from outside federal and commercial agencies, including the National Institutes of Health and National Science Foundation. Moreover, in order to foster collaboration, CTR grants require each grant proposal include an investigator from two or more academic campuses at the IU School of Medicine, IUPUI, IU Bloomington, Purdue or Notre Dame. The recipients and their projects are:
Arezoo Ardekani, Ph.D., of the Department of Mechanical Engineering, School of Engineering, at the University of Notre Dame, and Yves Brun, Ph.D., of the Department of Biology, School of Arts and Sciences, at Indiana University Bloomington, will receive $72,649 to support their project titled, "Transition from reversible to irreversible of bacterial adhesion to surfaces."
Ji-Xin Cheng, Ph.D., of the Department of Biomedical Engineering, Purdue School of Engineering, at Purdue University, and Shaoxiong Chen, M.D., Ph.D., of the Department of Pathology and Laboratory Medicine, IU School of Medicine, will receive $74,000 to support their project titled, "Prevention of Pancreatic Cancer Metastasis by Abrogating Cholesterol Metabolism." Additional project collaborators include Jingwu Xie, Ph.D., of the IU School of Medicine.
J. Dennis Fortenberry, M.D., of the Department of Pediatrics, IU School of Medicine, and Cleveland Shields, Ph.D., of the Child Development and Family Studies, Purdue School of Arts and Sciences, will receive $15,010 to support their project titled, "The PATH Study: Promoting Autonomy in Teen Health." Additional project collaborators include Alexander Stewart, Ph.D., of Purdue.
Robyn Fuchs, Ph.D., of the Department of Physical Therapy, IU School of Health and Rehabilitation Science, and Linda Dimeglio, M.D., of the Department of Pediatrics, IU School of Medicine, will receive $72,445 to support their project titled, "The Effect of Botox on Bone Health in Children with Cerebral Palsy."
Bumsoo Han, Ph.D., of the Department of Mechanical Engineering, School of Engineering, at Purdue, and Jian-Ting Zhang, Ph.D., of the Department of Pharmacology and Toxicology, IU School of Medicine, will receive $75,000 to support their project titled, "Rapid screening of drugs for multidrug resistant cancers using a new tumor-microenvironment-on-chip platform." Additional project collaborators include Kinam Park, Ph.D. of Purdue.
Fredrick Pavalko, Ph.D., of the Department of Cellular and Integrative Physiology, IU School of Medicine, and Angela Bruzzaniti, Ph.D., of the Department of Oral Biology, IU School of Dentistry at IUPUI, will receive $75,000 to support their project titled, "Biomechanical regulation of osteoporosis and osteoarthritis by tyrosine family kinases." Additional project collaborators include Hiroki Yokota, Ph.D., of IUPUI.
Jean-Christophe Rochet, Ph.D., of the Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy, at Purdue, and Kenneth Nephew, M.D., of the Cellular and Integrative Physiology, IU School of Medicine-Bloomington, will receive $74,500 to support their project titled, "Role of DNA methylation in Lewy body diseases."
Chandru Sundaram, Ph.D., of the Department of Urology, IU School of Medicine, and Philip Low, Ph.D., of the Department of Chemistry, at Purdue, will receive $72,500 to support their project titled, "Real time targeted imaging of renal cell carcinoma using folate guided fluorescence." Additional project collaborators include Clinton Bahler, M.D., of the IU School of Medicine.
William Truitt, Ph.D., of the Department of Anatomy and Cellular Biology, IU School of Medicine, and Riyi Shi, M.D., Ph.D., of the Department of Basic Medical Sciences, College of Veterinary Medicine, at Purdue, will receive $75,000 to support their project titled, "Mechanisms and treatment of depression in rats post mild blast-induced brain injury."
2013 Center of Excellence in Cardiovascular Research Grants
Five research teams from the IU School of Medicine will receive about $380,000 through the CECARE grant program. These grants, administered by Indiana CTSI on behalf of the Strategic Research Initiative-funded Center of Excellence in Cardiovascular Research, support clinical and translational research projects focused on cardiovascular health. This year's recipients are:
Sharon Moe, M.D., Stuart A. Kleit Professor of Nephrology and professor of medicine at the IU School of Medicine, will receive $117,000 to support her project titled, "Calcium as a cardiovascular toxin." Dr. Moe's collaborators are Neal Chen, M.D., Ph.D.; Chia-Hsiang Hsueh, Ph.D.; and Shien-Fong Lin, Ph.D., all of the IU School of Medicine
Irina Petrache, M.D., Dr. Calvin H. English Professor of Medicine and professor of biochemistry and molecular biology at the IU School of Medicine, will receive $120,000 to support her project titled, "Effect of alpha-1 antitrypsin on vascular endothelial function modulated by HDL signaling."
Michael Rubart von der Lohe, M.D., assistant research professor of pediatrics at the IU School of Medicine, will receive $120,000 to support his research project titled, "Myofibroblast arrhythmogeneicity in the chronically infarcted heart."
Michael Sturek, Ph.D., professor and chair of cellular and integrative physiology and professor of medicine at the IU School of Medicine, will receive $120,000 to support his project titled, "Imaging for Early Diagnosis of Unstable Plaque and Vascular Calcification." Dr. Sturek's collaborator on the project is Dr. Moe.
Johnathan Tune, Ph.D., associate professor of cellular and integrative physiology at the IU School of Medicine, will receive $117,954 to support his project titled, "Perivascular adipose and metabolic syndrome induced coronary disease."
2013 Fall Core Pilot Grants
Sixteen researchers from IU, Purdue and Notre Dame will receive about $150,000 through the core pilot grants program. Core pilot grants provide investigators access to more than 60 Indiana CTSI-approved core facilities across the IU, Purdue and Notre Dames campuses. The recipients and their projects are:
Tarek El-Achkar, M.D., of the Department of Medicine, IU School of Medicine, will receive $10,000 to access to the Physiological Proteomics Core at the IU School of Medicine in support of his project titled, "Proteomic Characterization of Tamm-Horsfall Protein Isoforms during Kidney Injury."
Michael Ferdig, Ph.D., of the Department of Biological Science, School of Science, at Notre Dame, will receive $10,000 to access the Genomics and Bioinformatics Core at Notre Dame in support of his project titled, "Expression Variation of Plasmodium falciparum Malaria: Implications for Adaptation and Evolution."
Anthony Firulli, Ph.D., of the Department of Pediatrics, IU School of Medicine, will receive $10,000 to access the IU Transgenic Animal/Embryonic Stem Cell Core at the IU School of Medicine in support of his project titled, "Molecular mechanisms of left ventricular growth and morphogenesis."
Craig Goergen, Ph.D., of the Department of Biomedical Engineering, School of Engineering, at Purdue, will receive $10,000 to access the Transgenic Mouse Core at Purdue in support of his project titled, "Creation of apolipoprotein E-deficient rats for the study of cardiovascular disease."
Eri Hashino, Ph.D., of the Department of Otolaryngology-Heck and Neck Surgery, IU School of Medicine, will receive $10,000 to access the Indiana Center for Biological Microscopy at the IU School of Medicine in support of her project titled, "3D reconstruction and functional imaging of inner ear organs derived from human pluripotent stem cells."
Reginald Hill, Ph.D., of the Department of Biological Sciences, School of Science, at Notre Dame, will receive $9,999 to access the Genomics and Bioinformatics Core at Notre Dame in support of his project titled, "Identifying Stromal MicroRNAs mediating chemoresistance in pancreatic cancer."
Jeffrey Kline, M.D., of the Department of Emergency Medicine, IU School of Medicine, will receive $9,172 to access the Chemical Genomics Core at the IU School of Medicine in support of his project titled, "Decoy peptide to inhibit α2antiplasmin binding to delta plasmin."
Stephen F. Konieczny, Ph.D., of the Department of Biological Sciences, College of Science, at Purdue will receive $9,900 to access the Center for Medical Genomics and Bioinformatics Cores at the IU School of Medicine in support of his project titled,"Identifying the Importance of the SOX9 Transcriptome in Pancreatic Cancer."
Liu Wanqing, Ph.D., of the Purdue School of Pharmacy, will receive $6,606 to access the Bioinformatics Core at the IU School of Medicine, in support of his project titled, A Genome-wide eQTL Mapping for Human Hepatic UGTs.
Seema Mattoo, Ph.D., Department of Biological Sciences, College of Science, at Purdue, will receive $10,000 to access the Proteomics Core at Purdue in support of her project titled, "Assessing Fic-mediated Post-Translational Modifications During Cancer Signaling."
Sharlene Newman, Ph.D., of the Department of Psychological and Brain Sciences, College of Arts and Sciences, IU Bloomington, will receive $10,000 to access the IU Imaging Research Facility at IU Bloomington in support of her project titled, "Neural and behavioral correlates of anomia treatment in acquired neurogenic disorders."
Karen E. Pollok, Ph.D., of the Department of Pediatrics, IU School of Medicine, will receive $10,000 to access the Flow Cytometry Resource Facility at the IU School of Medicine in support of her project titled, "Therapy-induced DNA Damage Response Kinetics in Nervous System Tumors measured by imaging flow cytometry using the ImageStreamX Mark II."
Alexander Robling, Ph.D., of the Department of Anatomy, IU School of Medicine, will receive $10,000 to access the Transgenic Mouse Core Facility at the IU School of Medicine, in support of his research project titled, "Generation of a novel mouse model for impaired Lrp4 function in bone."
Jean-Christophe Rochet, Ph.D., of the Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy, at Purdue, will receive $10,000 to access the Purdue Proteomics Facility Biophysical Analysis Lab at Purdue in support of his research project titled, "Biophysical approaches to characterize protective functions of the Parkinson's disease-related protein DJ-1."
Sarah Tersey, Ph.D., of the Department of Pediatrics, IU School of Medicine, will receive $7,008 to access the Islet Core at the IU School of Medicine in support of her project titled, "Role of Ornithine Decarboxylase in Pancreatic Islets."
Claire Walczak, Ph.D., of the Department of Biochemistry and Molecular Biology, IU School of Medicine, will receive $3,500 to access the Bioinformatics Core at the IU School of Medicine in support of her project titled, "Analysis of the Microtubule Depolymerizing Kinesin as a Prognostic Marker for Taxane Resistant Breast Cancers."